Twice married to a man once. First wife pregnant 8 times, but each time pregnancy abortion occurred less than two months. To the hospital, medical and reproductive system did not find anything wrong with both sides. Obviously the man his wife\'s miscarriage and he himself has direct responsibility. The men of defects in what place? Genetics check uncovered one of mystery, original chromosomal abnormalities of the men, balanced translocation occurs.
First of all we explain what is a balanced translocation of chromosomes? Human cells have 23 pairs (46) chromosomes. Number of chromosomes, the structure is relatively constant, just more or less, otherwise it will go wrong, such as Mongolism was on the 21st chromosome than normal one. When on a chromosome have a \"move\" to the other on a chromosome, called the balanced translocation of chromosomes. This had a chromosomal translocation of genetic material \"inside move\". But, in relation to a cell, the total number of chromosomes is unchanged, containing genes does not lack, so this will not show abnormal symptoms, their appearance and intelligence are normal, no defects in development, they are just chromosome translocation carriers. Check above said man cell chromosome chromosome found seems to be only the total number of 45, only after a careful analysis of chromosome 13th found a \"missing\", another is a 1 time times longer than normal, that he is 13th in the cell chromosome translocation, chromosome two 13th and into the article.
Why chromosome translocation results in habitual abortion? At the time of formation of germ cells in normal subjects, primary spermatocytes and primary oocytes have to undergo meiosis, 46 chromosomes into two parts, each sperm and eggs containing only 23 chromosomes. After fertilization, sperm-egg fusion, and 23 chromosomes from both parents and into 23 pairs, form a normal embryo. In the case of chromosome translocation, this distribution will appear uneven. Aforesaid man, due to the abnormal chromosome 13th not split properly, so produced after meiosis of sperm is not with two 13th chromosome, chromosome is less of a 13th. The sperm and egg will normally become a exception of three body or a single fertilized egg (normal for the two-body). Monomer form of eggs tend to die early in embryonic development, resulting in miscarriage or stillbirth; three-body forms of eggs is also prone to miscarriage, even if barely survive to birth, you must be a congenital deformity, it is difficult to grow up, become imbecile or development.
There is also a balanced translocation of chromosomes is a small segment of a chromosome and the other first Exchange of a small location on chromosome. For example part of the 15th chromosome to 3rd on a chromosome, chromosome and 3rd on a small piece of chromosome moved to 15th. Therefore, these two pairs of chromosomes in the chromosome 1 is normal, while the other one is an exception. When fertilization, if patients balance translocation of chromosomes chromosomes were normal, the embryo is normal, develop into a healthy children, if their chromosomes with 1 or 2 is in exception, formation of the embryo have unbalanced chromosome translocation, therefore appears in miscarriage, fetal death, birth defects, and so on.
Due to the lack of scientific knowledge, some people think that \"abortion is the issue of women,\" some women suffer from discrimination and even persecution. In recent years, as the work of medical genetics, chromosome technology of growing popularity has increasingly found that some cause of recurrent miscarriage was due to chromosome does not function properly, and both men and women alike who chromosome abnormalities can cause abortion. Balanced translocation of chromosomes but in patients with men, but women also. This carrier about 0.2% in the crowd, or 250 normal couple in a carrier. But in the event of a natural history of abortion in the crowd, carrying them, 5%, who married childbirth, there may be still births, stillbirths, miscarriages and birth defects, and other. All in all, abortion is not \"incrimination\" to the woman, the man sometimes have an unshirkable responsibility.
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